Exploring the Utility and Appropriateness of Dose Thresholds for Issuing of Public Drug Alerts on High-Dose MDMA: A Qualitative Study.

Abstract

<h4>Introduction</h4>Drug alerts are sometimes issued when samples are found to exceed a pre-determined dose threshold. In Australia, it is common for alerts to be issued when MDMA pills contain ≥ 150 mg of MDMA free-base or 179 mg hydrochloride. Nineteen such alerts were issued in Australia in 2024, raising concerns that repeat alerts may lose impact over time. This study examined experts' viewpoints on the appropriateness and utility of using a 150 mg threshold to trigger high-dose MDMA alerts.<h4>Methods</h4>Fifteen participants responsible for the design and dissemination of drug-alerts in Australia completed an online survey and seven participated in a focus group. The survey and focus group elicited reflections on the use of thresholds when issuing alerts about high-dose MDMA. Data were thematically analysed using a qualitative description methodology.<h4>Results</h4>Although thresholds are binary and cannot account for evolving trends in MDMA manufacture or consumption, most agreed that 150 mg free-base is a reasonable threshold for issuing alerts. It was noted that 150 mg of MDMA may cause harm, that high-dose alerts are contingent on a threshold, and that thresholds enable rapid communications. Due to Australia's limited capacity to monitor community perceptions of alerts, there was little evidence to justify a change in the threshold.<h4>Discussion and conclusions</h4>Notifying communities about products containing ≥ 150 mg MDMA remains a harm-reduction priority. Establishing a database containing dosage and purity results for all analytically tested samples and increasing efforts to monitor community responses to and perceptions of drug alerts may improve future risk communication.

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