Systematic Reviews and Meta-Analyses of Ketamine Therapy for Depression (2020–2024): A Comparative Evidence Summary
Abstract
This report reviews over 25 systematic reviews and meta-analyses (2020–2024) on ketamine-based treatments for depression. It compares the efficacy and speed of IV ketamine, esketamine nasal spray (Spravato), and oral ketamine. It also examines emerging data on ketamine-assisted psychotherapy. The goal is to provide patients, clinicians, and researchers with clear, evidence-based insights on real-world remission rates, onset times, and treatment reliability across methods.
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