Data from: 5-HT2ARs in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin

Abstract

<p>This data was collected to investigate the role of serotonin 2A receptors (5-HT2ARs) expressed in cortical layer 5 pyramidal neurons (L5 PyrNs) in psilocybin-induced hallucination-like behavior and synaptic neuroplasticity in mice. The dataset contains head-twitch response (HTR) counts recorded after psilocybin or saline injection, and dendritic spine dynamics measured by longitudinal in vivo two-photon imaging of apical tuft dendrites of L5 PyrNs in the somatosensory cortex of Thy1-GFP-M mice.</p>

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