Editorial: Novel Approaches to the Treatment of Suicidality and Depression in Youth.
Abstract
Suicide continues to be a major cause of mortality in adolescents with limited treatment options.<sup>1</sup><sup>,</sup><sup>2</sup> Effective treatments, both therapy and medication, are available for treating depression, but even with the best combination, treatment remission rates are low.<sup>3</sup> The most common approach to treating suicidality, which includes suicidal ideation and suicidal behavior, is to address concomitant depression. Ketamine and its enantiomers have shown rapid anti-suicidal effects in adults with MDD, and intranasal esketamine is approved for treating treatment-resistant depression (TRD) in adults.<sup>4</sup><sup>,</sup><sup>5</sup> The effectiveness of ketamine for the treatment of depression frequently lags behind the treatment of suicidality. There are also many methodological differences and barriers to assessing the effectiveness of short-term treatments. These include measurement of change over short time frames, measurement of suicidality, and so forth. Finally, the use of novel short-term treatments in treating chronic depression and suicidality in real-world situations is unclear.
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