Insight and Therapeutic Outcomes in a Randomised Controlled Trial of Psilocybin-Assisted Therapy for Generalised Anxiety Disorder

Abstract

Feelings of insight have been consistently reported in studies of psychedelic-assisted therapies, and emerging evidence correlates insight experiences with long-term therapeutic benefit. However, to date, evidence linking psychedelic-catalysed insight with therapeutic benefit is based on inconsistent and incomplete measurement of insight, and primarily comes from studies that have methodological limitations, such as a small sample size, survey or non-randomised design, lack of pre-registration and treating insight as an outcome of secondary or exploratory interest. This study will utilise data from a well-powered randomised controlled clinical trial of psilocybin-assisted therapy for GAD to investigate the prevalence and reliability of psychedelic-catalysed insight, and explore their relationship to clinical outcomes. In doing so, the results of this study will contribute to the currently active discussion surrounding the therapeutic status of subjective effects, such as insight, during psychedelic dosing sessions.

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