[Opioid insensitivity associated with genetic variants in the μ-opioid receptor].
Abstract
Interindividual variation in opioid response is well described, but complete insensitivity is exceedingly rare. In this case report, a healthy 32-year-old female demonstrated no clinical effect of large doses of opioids. Exome sequencing revealed two variants in the OPRM1 encoding the μ-opioid receptor, offering a plausible genetic explanation. The patient was anaesthetised for two laparoscopic procedures, and successful management relied on a multimodal strategy including esketamine and epidural analgesia.
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