Wang X

Interdisciplinary Laboratory for Frontier Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China. xiaohui.wang@ciac.ac.cn.

88 papers · 4 preprints · ORCID

ArticlePsilocybin

Psychedelics and disorders of consciousness: a new frontier in neurotherapeutics.

Du X, Peng F, Wang X

Europe PMC2026
ArticleKetamine

Samm50 downregulation-driven mitochondrial dysfunction triggers ferroptosis and contributes to ketamine-induced neurotoxicity and cognitive impairment.

Li Y, Dai X, Hu J +7

Europe PMC2026
ArticleKetamine

Esketamine exerts a protective effect against skeletal muscle injury induced by hindlimb ischemia-reperfusion in mice by regulating autophagy.

Liu J, Liu J, He T +7

Europe PMC2026
ArticleKetamine

Opioid-sparing anesthesia based on opioid-free principles for early recovery after total knee arthroplasty: A randomized controlled trial.

Liu J, Liu J, Liu P +6

Europe PMC2026
ArticlePsilocybin

Psychedelics and astrocytes: a hypothesis-driven perspective on neuro-glial integration, network plasticity, and neuroimmune reprogramming.

Ke X, Du X, Wang X

Europe PMC2026
ArticleKetamine

The impact of different intervention methods (anesthetic adjuvant drugs, anesthetic techniques, and non-pharmacological interventions) on postoperative cognitive function in patients undergoing cardiac surgery: a systematic review and Bayesian network meta-analysis.

Xue J, Wang X, Qiu Y

Europe PMC2026
ArticleKetamine

Epigenetic landscapes of classical psychedelics and ketamine: molecular mechanisms of long-lasting neuromodulation.

Lin C, Wang X

Europe PMC2026
ArticleKetamine

Regional anesthesia combined with esketamine analgesia and remimazolam sedation as a salvage strategy for intertrochanteric femur fracture surgery in a high-risk patient: A case report.

Wang X, Zhang J, Ren J +2

Europe PMC2026
ArticlePsilocybin

Chemical ecology and convergent evolution of natural hallucinogens: From ecological defense to conserved neural targets.

Wang Y, Wang H, Lin C +1

Europe PMC2026
ArticleKetamine

Esketamine improves postoperative sleep quality in thoracic surgery patients with preoperative sleep disturbance: a randomized controlled trial.

Wang X, Wang H, Luo H

Europe PMC2026
ArticleKetamine

Acute Effects of Esketamine on the EEG Power Spectrum and Signal Complexity in Prolonged Disorders of Consciousness: A Prospective Exploratory Cohort Study.

Liang Y, Yang W, Wang X +8

Europe PMC2026
ArticleKetamine

Esketamine alleviates trigeminal neuralgia and anxiety-like behaviors in mice by inhibiting RIPK1/RIPK3/MLKL-mediated necroptosis.

Dong R, Liu J, Shen Y +6

Europe PMC2026
ArticleKetamine

Multimodal opioid-free anesthesia containing esketamine versus opioid-based anesthesia: a systematic review and meta-analysis.

Fang Y, Gao M, Wang X +8

Europe PMC2026
ArticlePsilocybin

Overcoming Pharmacokinetic and Peripheral Safety Challenges in Psychedelic Therapies: The Promise of Advanced Drug Delivery Systems.

Zhang T, Lin C, Wang X

Europe PMC2026
ArticleKetamine

Ketamine and esketamine for the prevention of postpartum depression: A systematic review and network meta-analysis, with an integrated evidence synthesis.

Lunsky I, Gutierrez G, Wang X +8

Europe PMC2026
ArticleKetamine

Efficacy and safety of N-methyl-d-aspartate receptor antagonists for preventing acute postoperative pain: A systematic review and network meta-analysis of randomized controlled trials.

Zhou J, Wen Y, Xu S +3

Europe PMC2026
ArticleKetamine

Effects of Esketamine on Postoperative Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Zhao J, Yan Y, Wang X +2

Europe PMC2026
ArticlePsilocybin

The Harmonious Dance: A Narrative Review on Psychedelics and Music in Therapeutic Settings.

Wang H, Li X, Yu F +1

Europe PMC2026
ArticleKetamine

Esketamine for Postoperative Multimodal Analgesia in Laparoscopic Surgery: A Systematic Review and Meta-Analysis.

Li J, Wang X

Europe PMC2026
ArticlePsychedelics

Leveraging molecular dynamics simulations to study psychedelics and their receptors in future drug development.

Zhang C, Jiang P, Wang Y +1

Europe PMC2026
ArticleDMT

Evaluating use of disease-modifying therapies for multiple sclerosis using claims data.

Wang X, Zhao FL, Newby D +1

Europe PMC2026
ArticlePsilocybin

Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies.

Zhang J, Lin C, Lv X +2

Europe PMC2026
ArticleKetamine

Compatibility and stability of ciprofol with different concentrations of remifentanil or esketamine.

Cheng X, Fang B, Liu Q +5

Europe PMC2026
ArticleKetamine

A comprehensive review and meta-analysis on the safety and efficacy of esketamine for emerging delirium in elderly patients.

Lu Y, Wang X, Zou H +3

Europe PMC2026
ArticleKetamine

Intranasal esketamine plus dexmedetomidine versus dexmedetomidine alone for emergence delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials.

Wang Y, Liu C, Wu Y +7

Europe PMC2026
ArticleKetamine

Efficacy and safety of HR020602 in combination with propofol in children receiving general anesthesia: a multicenter, phase 2 study.

Zou N, Wang X, Wang F +10

Europe PMC2026
ArticleKetamine

Effect of Esketamine Combined with Lidocaine on Opioid Requirements in the Elderly Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized, Double-Blind, Controlled Trial.

Xie JX, Wang X, Li Y +5

Europe PMC2026
ArticleKetamine

Intestinal γδ T17-IL-17A signaling disrupts hippocampal mitophagy in stress-induced depression and is restored by arketamine.

Han M, Xie B, Yu Y +15

Europe PMC2025
ArticleKetamine

Prospective Dose-Finding of Esketamine for Suppressing Cervical Dilation Response in Ambulatory Hysteroscopy Under Monitored Anesthesia Care.

Yan L, Wang X, Wei J +2

Europe PMC2025
ArticleKetamine

Commentary on "effect of low-dose intraoperative esketamine on quality of recovery after laparotomy for gynecologic malignancy: a randomized controlled trial".

Shi M, Wang X, Bo L

Europe PMC2025
ArticleKetamine

The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery.

Shi M, Wang T, Wang W +4

Europe PMC2025
ArticleKetamine

Comments on "Effect of intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing laparotomy for gynecologic malignancy: a randomized controlled trial".

Su Z, Wang X, Ye X

Europe PMC2026
ArticleKetamine

Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial.

Li TT, He XL, Tang HL +3

Europe PMC2025
ArticlePsilocybin

Psychedelic 5-HT<sub>2A</sub> receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function.

Padawer-Curry JA, Krentzman OJ, Kuo CC +7

Europe PMC2025
ArticleKetamine

Propofol-esketamine versus propofol-fentanyl combinations for sedation in pediatric flexible fiberoptic bronchoscopy: a randomized controlled trial.

Wang X, Xie T, Wang D

Europe PMC2025
ArticlePsilocybin

The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health.

Du X, Liu J, Wang X +1

Europe PMC2025
PreprintKetamine

Esketamine for Postoperative Analgesia Improves Short-Term Postoperative Sleep Quality in Patients Undergoing Thoracoscopic Surgery: Study Protocol of a Single-Center, Prospective, Double-Blind Randomized Controlled Trial

Lin Y, Guan Y, Zhou Y +2

Europe PMC2025
ArticleKetamine

Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial.

Wang X, Yan L, Cai J +3

Europe PMC2025
ArticlePsilocybin

Exploring the therapeutic potential of psychedelics in treating substance use disorders.

Li Y, Li H, Wang H +1

Europe PMC2025
ArticlePsychedelics

Hypoxia, Psychedelics, and Terminal Lucidity: A Perspective on Neuroplasticity and Neuropsychiatric Disorders.

Zhang J, Du X, Li X +3

Europe PMC2025
ArticleKetamine

Effects of Esketamine on Post-Partum Depression in Patients With Different Personality Types Undergoing Caesarean Section: Randomised Controlled Trial.

Luo M, Tang N, Guo Y +2

Europe PMC2025
PreprintKetamine

Effects of Different Doses of Esketamine on Postoperative Analgesia and Recovery Quality in Lumbar Decompression Surgery: A Randomized Controlled Trial Focusing on the Advantages of Sub-Anesthetic Doses

Liu J, Wang X, Ding P +2

Europe PMC2025
ArticleKetamine

Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.

Fu C, Li X, Liu X +16

Europe PMC2025
ArticlePsilocybin

Psychedelics, Spirituality, and Fundamentalism: A Brain Network Approach to Cognitive Flexibility and Rigidity.

Yang A, Lv X, Wang H +1

Europe PMC2025
ArticlePsilocybin

Psychedelics and the Gut Microbiome: Unraveling the Interplay and Therapeutic Implications.

Wang X, Jun F, Lin C +1

Europe PMC2025
ArticleKetamine

Microglial BDNF modulates arketamine's antidepressant-like effects through cortico-accumbal pathways.

He L, Wang X, Luo S +8

Europe PMC2025
ArticlePsilocybin

The Medial Prefrontal Cortex Modulates Psychedelic-like Effects of Psilocin.

Zhang M, Zhai H, Yang L +3

Europe PMC2025
ArticleKetamine

Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.

Wu Y, Yang Y, Wang X +5

Europe PMC2025
ArticlePsychedelics

Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.

Zhang C, Wang Y, Wang X

Europe PMC2025
ArticleKetamine

Effects of mini-dose esketamine-dexmedetomidine combination supplemented intravenous analgesia on postoperative sleep quality in elderly patients after total knee arthroplasty: a protocol of double-blind randomised trial.

Wang X, Ji X, Liu C +2

Europe PMC2025
ArticlePsilocybin

The Intersection of Psychedelics and Sleep: Exploring the Impacts on Sleep Architecture, Dream States, and Therapeutic Implications.

Zhai H, Wang H, Li H +1

Europe PMC2025
ArticlePsilocybin

Psilocybin and Obsessive-Compulsive Disorder: Exploring New Therapeutic Horizons.

Yang L, Li H, Wang X +1

Europe PMC2025
ArticleKetamine

Delirium risk associated with esketamine, sevoflurane, propofol, and dexmedetomidine: A real-world study based on the FDA adverse event reporting system.

Shuai Y, Liu Y, Yang X +3

Europe PMC2025
ArticlePsychedelics

Entheogen: an evolutionary medicine for neuropsychiatric disorders.

Wang Y, Wang X

Europe PMC2025
ArticlePsilocybin

Exploring the Role of Psychedelics in Modulating Ego and Treating Neuropsychiatric Disorders.

Wang H, Wang X

Europe PMC2025
ArticlePsilocybin

Psilocybin biosynthesis enhancement through gene source optimization.

Keller MR, McKinney MG, Sen AK +9

Europe PMC2025
ArticleKetamine

Effect of Esketamine Compared with Sufentanil Combined with Propofol in Patients Undergoing First Trimester Surgical Abortion: A Randomized, Double-Blinded Clinical Trial.

Guan Y, Wang H, Cong X +3

Europe PMC2025
ArticleKetamine

Investigating the Mechanisms of Esketamine in Treating Propofol-Induced Cognitive Impairment in Elderly Rats.

Zhang J, Xu G, Wang X +1

Europe PMC2025
ArticleKetamine

Chiral analysis of ketamine enantiomers in human urine and hair: Application to authentic cases of ketamine use.

Zhang Z, Shi Y, Lin M +4

Europe PMC2025
ArticleMDMA

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine-Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms.

Li Y, Li H, Wang H +1

Europe PMC2025
ArticlePsilocybin

Psychedelics and Eating Disorders: Exploring the Therapeutic Potential for Anorexia Nervosa and Beyond.

Hu S, Lin C, Wang H +1

Europe PMC2025
ArticleMDMA

Special issue on "Ketamine, MDMA, and psychedelics in the treatment of neuropsychiatric disorders".

Hashimoto K, Wang X, Zhang J

Europe PMC2025
ArticlePsychedelics

Exploring End-of-Life Experiences and Consciousness through the Lens of Psychedelics.

Li H, Wang X, Wang X

Europe PMC2025
ArticlePsychedelics

Psychedelics and the Autonomic Nervous System: A Perspective on Their Interplay and Therapeutic Potential.

Li H, Wang H, Wang X

Europe PMC2025
ArticlePsilocybin

Psychedelics and Pro-Social Behaviors: A Perspective on Autism Spectrum Disorders.

Wang X, Lin C, Wang X

Europe PMC2025
ArticlePsychedelics

Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine.

Lin C, Wang X, Wang X

Europe PMC2025
ArticleKetamine

Effects of repeated intravenous esketamine administration on affective biases.

Reif-Leonhard C, Millard SN, Ferdowssian D +9

Europe PMC2025
ArticleKetamine

Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.

Wang H, Wang Z, Zhang J +4

Europe PMC2025
ArticleKetamine

Effects of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy.

Zhu Y, Wang X, Wang L +1

Europe PMC2025
ArticleKetamine

Efficacy and safety of perioperative application of esketamine on postoperative depression: a meta-analysis of randomized controlled studies.

Wen Y, Mao M, Jiang M +6

Europe PMC2025
ArticleKetamine

Effects of Esketamine Combined with Dexmedetomidine on Early Postoperative Cognitive Function in Elderly Patients Undergoing Lumbar Spinal Surgery: A Double-Blind Randomized Controlled Clinical Trial.

Tao QY, Liu D, Wang SJ +5

Europe PMC2024
ArticlePsilocybin

Structural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT<sub>2A</sub> receptor activation and psychedelic-like activity.

Zhang M, Yang Y, Yang Z +7

Europe PMC2025
ArticleKetamine

Repeated high-dose esketamine in early postnatal rats leads to behavioural deficits with long-term modifications in white matter microstructural integrity.

Zhou L, Wang X, Cao T +3

Europe PMC2025
ArticlePsychedelics

A perspective on Alzheimer's disease: exploring the potential of terminal/paradoxical lucidity and psychedelics.

Lin C, Du X, Wang X +1

Europe PMC2024
ArticlePsychedelics

Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy.

Zhang M, Wang Y, Gao TM +1

Europe PMC2024
ArticleKetamine

The Effect of Opioid-Free Anesthesia with Transversus Abdominis Plane Block on Patients Undergoing Laparoscopic Sleeve Gastrectomy: Randomized Controlled Study.

Zhou X, Feng W, Wang X +4

Europe PMC2024
ArticleKetamine

Intravenous patient-controlled analgesia with esketamine improves early depressive symptoms in patients with postherpetic neuralgia: a single-center retrospective cohort study.

Qiu L, Chen X, Fu J +2

Europe PMC2024
ArticleKetamine

CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.

Hu N, Zheng Y, Liu X +5

Europe PMC2025
ArticleKetamine

Effect of esketamine on hypotension in women with preoperative anxiety undergoing elective cesarean section: a randomized, double-blind, controlled trial.

Qi Y, Zhou M, Dong Y +8

Europe PMC2024
ArticleKetamine

Ketamine and its two enantiomers in anesthesiology and psychiatry: A historical review and future directions.

Hashimoto K, Zhao M, Zhu T +2

Europe PMC2024
ArticleKetamine

Effect of esketamine on haemodynamic fluctuations in patients undergoing hysteroscopic surgery: A prospective, double-blind randomized clinical trial.

Guan Y, Pan H, Cong X +6

Europe PMC2024
ArticleKetamine

A scientometric analysis of research on the role of NMDA receptor in the treatment of depression.

Chen X, Wang X, Li C +3

Europe PMC2024
ArticlePsilocybin

Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities.

Kanis FC, Broude CN, Hellwarth EB +5

Europe PMC2024
ArticleKetamine

Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures.

Yao H, Wang X, Chi J +8

Europe PMC2024
ArticleKetamine

Efficacy and safety of perioperative application of esketamine on postpartum depression: A meta-analysis of randomized controlled studies.

Wen Y, Mao M, Wang X +7

Europe PMC2024
ArticleKetamine

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway.

Hu N, Chen X, Chen C +7

Europe PMC2023
ArticleKetamine

Opioid Free Total Intravenous Anesthesia With Dexmedetomidine-Esketamine-Lidocaine for Patients Undergoing Lumpectomy.

Qian XL, Li P, Chen YJ +3

Europe PMC2023
PreprintPsilocybin

Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling.

Padawer-Curry JA, Krentzman OJ, Kuo C +7

Europe PMC2023
ArticleKetamine

Opioid-Free Versus Opioid-Based Anesthesia on Postoperative Pain After Thoracoscopic Surgery: The Use of Intravenous and Epidural Esketamine.

Yan H, Chen W, Chen Y +11

Europe PMC2023
ArticleKetamine

Effect of esketamine on opioid consumption and postoperative pain in thyroidectomy: A randomized controlled trial.

Wang P, Song M, Wang X +2

Europe PMC2023
PreprintKetamine

Effects of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy

zhu y, Wang X, Yuan M +2

Europe PMC2023
ArticleLSD

Concentrations of LSD, 2-oxo-3-hydroxy-LSD, and iso-LSD in hair segments of 18 drug abusers.

Zheng J, Wang X, Zhang J +3

Europe PMC2023