Psychedelics and the Gut Microbiome: Unraveling the Interplay and Therapeutic Implications.
Abstract
Classic psychedelics and the gut microbiome interact bidirectionally through mechanisms involving 5-HT<sub>2A</sub> receptor signaling, neuroplasticity, and microbial metabolism. This viewpoint highlights how psychedelics may reshape microbiota and how microbes influence psychedelic efficacy, proposing microbiome-informed strategies─such as probiotics or dietary interventions─to personalize and enhance psychedelic-based mental health therapies.
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