Wang Y

Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

84 papers · 4 preprints · ORCID

ArticlePsychedelics

Mechanistic Basis for 5-HT<sub>2A</sub>R Over 5-HT<sub>2B</sub>R Activation.

Tang L, Ji X, Wang Y +5

Europe PMC2026
ArticleDMT

Psychedelic 4-AcO-DMT attenuated looming-induced freezing behaviors by activating PrL <sup>CaMKIIα</sup> neurons in mice.

Xia K, Wang Y, Liu J +3

Europe PMC2026
ArticleKetamine

Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodological and Reporting Considerations [Response to Letter].

Wang Y, Hong L, Wang P +1

Europe PMC2026
ArticleKetamine

Esketamine Use and Attempted Suicide or Intentional Self-Harm Among Individuals with Treatment-Resistant Depression: A Retrospective Cohort Study.

Wang Y, Storaci AS, Alexander GC +1

Europe PMC2026
ArticleKetamine

Esketamine Ameliorates Propofol-Induced Long-Term Cognitive Impairments in Juvenile Rats by Suppressing Autophagy via Activating the PI3K/Akt/mTOR Signaling Pathway.

Wang Y, Li Y, Chen Z +4

Europe PMC2026
PreprintKetamine

The Effects of Different Doses of Intravenous Esketamine on Postoperative Sleep and Chronic Pain in Patients Undergoing Thoracoscopic Lung Resection Surgery: A Randomized Controlled Trial

Li Y, Wang Y, Jin L +3

Europe PMC2026
ArticlePsychedelics

Hippocampal synaptic transmission and Ca<sup>2</sup>⁺ signaling are altered by the selective 5-HT<sub>2A</sub> receptor agonist, 25CN-NBOH.

Wang Y, Karaca SC, Rasmussen MD +2

Europe PMC2026
ArticleKetamine

Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.

Gu T, Zhang J, Wang R +10

Europe PMC2026
ArticleKetamine

Esketamine as an Adjuvant to Levobupivacaine in Thoracic Paravertebral Block for Thoracoscopic Lung Cancer Surgery: A Retrospective Propensity Score-Matched Cohort Study.

Jing Y, Jiang X, Hu B +3

Europe PMC2026
ArticleKetamine

Effect of opioid-free anesthesia on postoperative recovery in elderly patients undergoing laparoscopic abdominal surgery: a randomized controlled trial.

Zhao Q, Wang Y, Huang F +2

Europe PMC2026
ArticleKetamine

Ultrasound-Guided Femoral Nerve Block with Esketamine Adjuvant for Postoperative Analgesia in Total Knee Arthroplasty-A Randomized, Double-Blind, Controlled Trial.

Cheng Z, Hong L, Wang Y +1

Europe PMC2026
ArticleKetamine

Effects of sub-anesthetic doses of esketamine on immune function and postoperative negative emotions in acoustic neuroma patients: a randomized clinical trial.

Chen Z, Wang Y, Cong P +12

Europe PMC2026
ArticleKetamine

Mitochondrial-inflammation crosstalk in major depressive disorder: molecular mechanisms and therapeutic implications.

Wang Y, Li JT, Zhu LL +3

Europe PMC2026
ArticlePsilocybin

Chemical ecology and convergent evolution of natural hallucinogens: From ecological defense to conserved neural targets.

Wang Y, Wang H, Lin C +1

Europe PMC2026
ArticleKetamine

Efficacy and Safety of Ultrasound-Guided Erector Spinae Plane Block at Different Injection Depths for Percutaneous Kyphoplasty: A Randomized Controlled Trial.

Liu Y, Yu Y, Gao X +3

Europe PMC2026
ArticleKetamine

Effect of postoperative esketamine on depression after pancreatoduodenectomy: a randomized controlled trial.

Zhang B, Wang Z, Yu K +9

Europe PMC2026
ArticleKetamine

Esketamine attenuated sepsis-induced organ injury in mice via the TGF-β-Smad3 signaling pathway.

Haolan, Wang Y, Gao Y +5

Europe PMC2026
ArticleKetamine

Esketamine and postoperative cognitive dysfunction in aged mice: Role of the SIRT3/AMPK/mTOR pathway.

Wang Y, Cui T, Wang J +3

Europe PMC2026
ArticleMescaline

The complete chloroplast genome sequence of <i>Lophophora diffusa</i>.

Zhang T, Li N, Cui Z +2

Europe PMC2026
ArticleKetamine

Effect of Dexmedetomidine Combined with Esketamine on Postoperative Fatigue in Patients Undergoing Total Laparoscopic Hysterectomy: A Single-Center Randomized Double-Blinded Controlled Trial.

Wu L, Wang Y, Chai Y +4

Europe PMC2026
ArticleKetamine

Neuroprotective Effects of Esketamine in Central Nervous System Disorders: Mechanisms and Cellular Targets.

Zhao C, Wang Y, Wu J +1

Europe PMC2026
ArticlePsychedelics

Leveraging molecular dynamics simulations to study psychedelics and their receptors in future drug development.

Zhang C, Jiang P, Wang Y +1

Europe PMC2026
ArticleDMT

5-HT<sub>2A</sub> receptors in the prelimbic cortex VIP-expressing interneurons: A mechanism for psychedelic-induced innate fear attenuation.

Wang Y, Yao Y, Su R +1

Europe PMC2026
ArticlePsilocybin

Therapeutic effects of psilocybin in major depressive disorder: a systematic review and meta-analysis exploring dose effects.

He Z, Wang Y, Chen J +4

Europe PMC2026
ArticlePsilocybin

Acute psilocin increased cortical activity in rat.

Liu J, Wang Y, Xia K +5

Europe PMC2026
ArticleDMT

The Mediating Effects of Digital Music Therapy on Depressive Symptoms in Youth During the COVID-19 Pandemic: A Randomized Controlled Trial.

Zhu Y, Tang R, Zhang H +7

Europe PMC2026
ArticlePsilocybin

Single-dose psilocybin promotes cell-type-specific changes of neurons in the orbitofrontal cortex.

Huang Z, Wei X, Wang Y +5

Europe PMC2026
ArticleKetamine

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial.

Wang Y, Lin X, Zou X +7

Europe PMC2026
ArticleKetamine

Intranasal esketamine plus dexmedetomidine versus dexmedetomidine alone for emergence delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials.

Wang Y, Liu C, Wu Y +7

Europe PMC2026
ArticleKetamine

Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial

Dai Z, Yang M, Liu H +4

Europe PMC2026
ArticleKetamine

Esketamine/Ketamine: Dual-Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology.

Wang Y, Xu J, Zhou X +5

Europe PMC2026
ArticleKetamine

Effects of Esketamine-Dexmedetomidine Combination on Immediate Postprocedural Oxygenation Index in Severe Pneumonia Patients Undergoing Bedside Fiberoptic Bronchoscopic Sputum Aspiration: A Prospective Randomised Controlled Trial.

Wang Y, Zhang R, Wu B +3

Europe PMC2025
ArticleKetamine

Prefrontal neurophysiological changes associated with subanesthetic esketamine accelerating mice emergence from propofol anesthesia.

Sun Y, Li B, Wang Y +4

Europe PMC2025
ArticleKetamine

Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: A randomised, placebo-controlled, double-blinded clinical trial.

Zhang ZN, Hao XY, Cai C +13

Europe PMC2025
ArticleKetamine

Different interventions in preventing sufentanil-induced cough: a systematic review and network meta-analysis.

Liu H, He Y, Ding L +5

Europe PMC2025
ArticleKetamine

Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook.

Li C, Wang Z, Ye X +11

Europe PMC2025
ArticleKetamine

Letter to the Editor: Comments on the manuscript entitled 'Effect of intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing laparotomy for gynecologic malignancy: a randomized controlled trial'.

Yang Y, Wang Y, Yang Y

Europe PMC2026
ArticleKetamine

Effect of esketamine as an adjuvant of ropivacaine on the efficacy of supraclavicular brachial plexus block in radius fracture surgery: a randomized controlled trial.

Liu J, Zhang Y, Zhang R +5

Europe PMC2025
ArticleKetamine

Comparison of opioid-free versus weak-opioid general anesthesia on quality of postoperative recovery in soldiers undergoing arthroscopic meniscal surgery.

Sun X, Ding X, Han X +3

Europe PMC2025
ArticlePsychedelics

In Silico Characterization of Bromo-DragonFLY Binding to the 5-HT<sub>2A</sub> Receptor: Molecular Insights Into a Potent Designer Psychedelic.

Tariq SS, Qureshi U, Mushtaq M +5

Europe PMC2026
ArticleKetamine

The Early Effects of Esketamine on the Tumor Metastatic Microenvironment in Postoperative Lung Cancer Patients.

Wang Y, Li W, Jia L +3

Europe PMC2025
ArticleKetamine

Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling.

Cheng X, Jiang F, Liu L +3

Europe PMC2025
ArticleKetamine

Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial.

Wang Z, Li H, Wang Y +4

Europe PMC2025
ArticleKetamine

Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.

Fu C, Li X, Liu X +16

Europe PMC2025
PreprintKetamine

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in patients undergoing cesarean section: A randomized controlled tria

Wang Y, Lin X, Zou X +7

Europe PMC2025
ArticlePsychedelics

Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.

Zhang C, Wang Y, Wang X

Europe PMC2025
ArticleKetamine

Opioid-Free Anesthesia Improved the Quality of Recovery After Thyroidectomy Through Pre-Emptive and Preventive Analgesia: A Randomized Controlled Trial.

Zhang Y, Xian X, Wang F +5

Europe PMC2025
PreprintKetamine

Ultrasound-Guided Thoracic Paravertebral Block with Levobupivacaine-Esketamine Combination for Thoracoscopic Lung Cancer Surgery

Jing Y, Jiang X, Hu B +3

Europe PMC2025
ArticleKetamine

Esketamine combined with low-dose propofol induction strategy for category-1 cesarean section: a case series.

Zhu GQ, Wang Y, Wang XX +2

Europe PMC2025
ArticlePsychedelics

Entheogen: an evolutionary medicine for neuropsychiatric disorders.

Wang Y, Wang X

Europe PMC2025
ArticleKetamine

Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists.

Chen M, Jin J, Bi H +4

Europe PMC2025
ArticleKetamine

Effect of perioperative intravenous ketamine on postoperative sleep disturbance in patients undergoing non-cardiac surgery: A systematic review and meta-analysis.

Yang N, Peng L, Kuang R +3

Europe PMC2025
ArticleLSD

Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential.

Tuck JR, Dunlap LE, Khatib YA +27

Europe PMC2025
ArticleKetamine

Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study.

Li T, Han L, Wu Z +2

Europe PMC2025
ArticlePsychedelics

The Selective 5HT<sub>2A</sub> Receptor Agonist, 25CN-NBOH Exerts Excitatory and Inhibitory Cellular Actions on Mouse Medial Prefrontal Cortical Neurons.

Wang Y, Kristensen JL, Kohlmeier KA

Europe PMC2025
ArticleKetamine

Esketamine alleviates depressive-like behavior in neuropathic pain mice through the METTL3-GluA1 pathway.

Ji X, Huang Z, Zhou C +7

Europe PMC2025
ArticleKetamine

Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study.

Liu C, Wang Y, Yin Y +7

Europe PMC2025
ArticleKetamine

Effects of epidural esketamine versus sufentanil on labor analgesia and postpartum depression: a retrospective cohort study.

Li K, Chai Z, Deng C +5

Europe PMC2025
ArticleKetamine

Effect of subanesthetic dose of esketamine on early postoperative depression in elderly patients with Sarcopenia.

Fang Y, Cao G, Hu S +2

Europe PMC2024
ArticleKetamine

A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial.

Li N, Qi X, Bao J +6

Europe PMC2024
ArticlePsilocybin

Structural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT<sub>2A</sub> receptor activation and psychedelic-like activity.

Zhang M, Yang Y, Yang Z +7

Europe PMC2025
ArticleKetamine

Effect of different doses of esketamine on the median effective concentration of propofol for inhibiting body movement during hysteroscopy.

Wan JX, Zeng SS, Wu ZQ +3

Europe PMC2024
ArticlePsilocybin

Neuroprotective effects of psilocybin in a rat model of stroke.

Yu SJ, Wu KJ, Wang YS +4

Europe PMC2024
ArticlePsychedelics

Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy.

Zhang M, Wang Y, Gao TM +1

Europe PMC2024
ArticleKetamine

Inflammatory cytokines, cortisol, and anhedonia in patients with treatment-resistant depression after consecutive infusions of low-dose esketamine.

Wang Y, Yang Q, Chen C +3

Europe PMC2025
ArticleKetamine

Effects of subanesthetic repeated esketamine infusions on memory function and NGF in patients with depression: An open-label study.

Yang Q, Yao Y, Yuan X +4

Europe PMC2025
ArticleKetamine

Accurate Machine Learning-based Monitoring of Anesthesia Depth with EEG Recording.

Tu Z, Zhang Y, Lv X +9

Europe PMC2025
ArticleKetamine

The CB2-PKC pathway is involved in esketamine-induced anti-inflammation in BV-2 microglial cells exposed to lipopolysaccharides.

Wang Y, Cao M, Zhang Y +3

Europe PMC2024
ArticleKetamine

Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway.

Shi J, Song S, Wang Y +4

Europe PMC2024
ArticleKetamine

Opioid-free anesthesia improves postoperative recovery quality of small and medium-sized surgery: a prospective, randomized controlled study.

Wang P, Zhou X, Wang S +6

Europe PMC2024
ArticleLSD

Structural basis of psychedelic LSD recognition at dopamine D<sub>1</sub> receptor.

Fan L, Zhuang Y, Wu H +9

Europe PMC2024
ArticlePsilocybin

Efficacy and safety of eight enhanced therapies for treatment-resistant depression: A systematic review and network meta-analysis of RCTs.

Guo Q, Guo L, Wang Y +1

Europe PMC2024
ArticleKetamine

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis.

Wang Y, Chang S, Chen D

Europe PMC2024
ArticleKetamine

Pharmacovigilance of esketamine nasal spray: an analysis of the FDA adverse event reporting system database.

Liu R, Liu C, Feng D +2

Europe PMC2024
ArticleKetamine

The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery.

Wang Y, Ma B, Wang C +3

Europe PMC2024
ArticleKetamine

Effects of esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: a randomized controlled trial.

Lin X, Feng X, Sun L +8

Europe PMC2024
ArticleKetamine

Effect of Continuous Infusion of Different Doses of Esketamine on the Bispectral Index During Sevoflurane Anesthesia: A Randomized Controlled Trial.

Ren L, Yang J, Li Y +1

Europe PMC2024
ArticleKetamine

Effect of subanesthetic dose of esketamine on postoperative pain in elderly patients undergoing laparoscopic gastrointestinal tumor Surgery:A prospective, double-blind, randomized controlled trial.

Jing Z, Han Y, Li Y +4

Europe PMC2024
ArticleKetamine

Comparison of the analgesic effect of dezocine and esketamine in combination with sufentanil respectively after laparoscopic cholecystectomy: a prospective randomized controlled study.

Deng B, Wang D, Xie Z +4

Europe PMC2024
PreprintPsilocybin

Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seq

Huang Z, Wei X, Wang Y +5

Europe PMC2024
ArticleKetamine

Effects of adding low-dose esketamine to sufentanil and propofol sedation during cervical conization: a single-centre, randomized controlled trial.

Si J, Li X, Wang Y +2

Europe PMC2024
ArticleKetamine

Supplemental low-dose esketamine to propofol versus propofol alone on perioperative characteristics in children undergoing surgery: a prospective randomized controlled trial.

Han D, Du X, Li Y +5

Europe PMC2024
ArticleKetamine

Efficacy and safety comparison of esketamine-propofol with nalbuphine-propofol for upper gastrointestinal endoscopy in children: a multi-center randomized controlled trial.

Zheng X, Huang J, Wei S +6

Europe PMC2023
ArticleKetamine

Preoperative Esketamine Alleviates Postoperative Pain after Endoscopic Plasma Adenotonsillectomy in Children.

Liu F, Kong F, Zhong L +3

Europe PMC2023
ArticlePsilocybin

Acute psilocybin increased cortical activities in rats.

Liu J, Wang Y, Xia K +5

Europe PMC2023
ArticleKetamine

Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial.

Zheng L, Wang Y, Ma Q +8

Europe PMC2023
ArticleKetamine

Esketamine combined with pregabalin on acute postoperative pain in patients undergoing resection of spinal neoplasms: study protocol for a randomized controlled trial.

Sun W, Wang J, Wang J +4

Europe PMC2023
ArticlePsilocybin

Matrix-assisted laser-desorption/ionization-mass spectrometric imaging of psilocybin and its analogues in psychedelic mushrooms using a cesium chloride-coated target plate.

Wang H, Wang Y

Europe PMC2023