Validation and Clinical Application of the Chinese Version of Rapid Response Scale
Abstract
<title>Abstract</title> <p><bold>Background</bold> Current assessment tools inadequately capture rapid symptom changes. This study aims to translate, validate and explore clinical application of the Chinese version of the McIntyre and Rosenblat Rapid Response Scale (CMRRRS) for rapid onset antidepression treatment. <bold>Methods</bold> The McIntyre and Rosenblat Rapid Response Scale (MARRRS) was translated and culturally adapted. 71 MDD patients undergoing esketamine treatment were assessed utilizing CMRRRS and other validated scales. Reliability, validity, and sensitivity were evaluated through Cronbach’s alpha, correlation with established scales, exploratory factor analysis and mixed-effects modeling. Latent Profile Analysis and Kernel Density Estimation curves were utilized for classification. Minimum Clinically Important Difference was determined to explore minimum change that related to treatment response evaluation. <bold>Results</bold> The CMRRRS showed high reliability and robust validity. Factor analysis result explaining over 60% of variance. Latent Profile Analysis revealed three classes with distinct thresholds determined by Kernel Density Estimation. 5 points was optimal for detecting minimum clinically meaningful changes. <bold>Conclusion</bold> The CMRRRS is a reliable, valid, and sensitive tool for tracking rapid symptom changes in MDD patients treated with esketamine. It supports real-time symptom monitoring and personalized treatment adjustments. Further studies are recommended to explore its broader applicability.</p>
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